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CCND1 Breakapart

Applications
haematopathology
Catalogue Numbers
LPS 030 (10 tests)
LPS 030-S (5 tests)

The Cyclin D1 (CCND1) gene located at 11q13.3 encodes a protein that belongs to the highly conserved cyclin family. Mutations, amplifications and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumours and may contribute to tumourigenesis1.

Cyclins function as regulators of cyclin dependent kinases (CDKs). CCND1 forms a complex with, and functions as a regulatory subunit of, CDK4 or CDK8, whose activity is required for the G1/S transition through the cell cycle1. The translocation t(11;14)(q13;q32) between CCND1 and Immunoglobulin Heavy chain (IGH) has been described as the molecular hallmark for Mantle Cell Lymphoma (MCL)2,5, a subtype of B-cell non-Hodgkin Lymphoma, and results in overexpression of cyclin D1. This translocation is estimated to occur in 53-93% of MCL cases3 and has also been implicated in 10-25% of Multiple Myeloma patients with abnormal cytogenetics4.

References

1. RefSeq, Jul 2008

2. Vose JM, et al., Am J Hematol 2012;87(6):604-9

3. Rahman K et al., Indian J Pathol 2012;55:66-71

4. Hoyer JD et al., Am J Clin Pathol 2000;113(6):831-7

5. Avet-Loiseau et al., Genes Chromosomes Cancer. 1998; 23(2):175-82

Microscope Images

CCND1 Breakapart magnified
Area of Interest*
Lymphoma, Breast Cancer, Gastric Cancer

Disclaimer

This product is intended to be used on Carnoy’s solution (3:1 methanol/acetic acid) fixed haematological samples, or formalin-fixed paraffin-embedded (FFPE) tissues.

*Disease information supported by the literature and is not a reflection of the intended purpose of this product.