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MALT1 Breakapart

Applications
haematopathology
Catalogue Numbers
LPS 017 (10 tests)
LPS 017-S (5 tests)

Extranodal marginal zone B-cell lymphoma (MZBCL) of the Mucosa-Associated Lymphoid Tissue (MALT) type is characterised by two main translocations involving MALT1; t(11;18)(q21;q21.32) and t(14;18)(q32;q21.32)1. Other MALT1 associated translocations are rare1.

However, there are no MALT1 translocations in nodal or splenic lymphomas1. The t(11;18) BIRC3 (Baculoviral IAP repeat containing 3 protein2,3)/MALT1 translocation is present in 18-33% of cases of MALT lymphoma2 and the resulting fusion protein induces NF-κB (nuclear factor kappa-light-chain-enhancer of activated B-cells), resulting in transcriptional activation3. 18% of MALT lymphomas harbour the t(14;18) MALT1/IGH translocation4.

The genetic abnormalities in MALT lymphomas reflect their site of origin. The t(14;18) translocation was most frequently found in MALT1 lymphomas of the parotid gland, liver, skin, and ocular adnexa – sites rare for the t(11;18). However, the pulmonary and gastrointestinal MALT lymphomas show high frequencies of t(11;18) and absence of the t(14;18)1,4.

References

1. Murga PEM et al., Leukemia 2003;17(11):2225-9

2. Auer IA et al., Ann Oncol 1997;8(10):979-85

3. Lucas PC et al., J Biol Chem 2001;276(22):19012-9

4. Streubel B et al., Blood 2003;101(6):2335-9

Microscope Images

MALT1 Breakapart magnified
Area of Interest*
Lymphoma

Disclaimer

This product is intended to be used on Carnoy’s solution (3:1 methanol/acetic acid) fixed haematological samples, or formalin-fixed paraffin-embedded (FFPE) tissues.

*Disease information supported by the literature and is not a reflection of the intended purpose of this product.