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EML4 Breakapart

Applications
pathology
Catalogue Numbers
LPS 020 (10 tests)
LPS 020-S (5 tests)

The protein encoded by the echinoderm microtubule associated protein-like 4 (EML4) gene is involved in microtubule formation and stabilisation1.

A novel gene fusion of EML4 and Anaplastic Lymphoma Kinase (ALK) was recently identified in Non-Small Cell Lung Cancer (NSCLC).

The EML4-ALK fusion was shown to result from an inversion within chromosome 2p, inv(2)(p21p23), and was detected in approximately 7% of NSCLC cases2,3.

References

1. Xuchao Zhang et al., Mol Cancer Res 2010;9:188

2. Lin et al., Mol Cancer Res 2009;7(9):1466-1476

3. Martelli et al., AJP 2009;174(2):661-670

Microscope Images

EML4 Breakapart magnified
Area of Interest*
Lung Cancer

Disclaimer

This product is intended to be used on formalin-fixed paraffin-embedded (FFPE) tissues.

*Disease information supported by the literature and is not a reflection of the intended purpose of this product.