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PAX7 Breakapart

Catalogue Numbers
LPS 013 (10 tests)
LPS 013-S (5 tests)

Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in children. One of the primary histological subtypes is the alveolar RMS (ARMS)1.

The majority (55%) of ARMS are associated with the t(2;13)(q36.1;q14) translocation, and less commonly (22%) with t(1;13)(p36;q14), leading to the fusion of transcription factor FOXO1 (Forkhead Box protein 1) to the transcription factors PAX3 (Paired Box protein 3) and PAX7, respectively2. The distinction between the t(1;13) and t(2;13) in ARMS is important as patients with the t(2;13) have a more adverse outcome than those with the t(1;13)3.

In ARMS cases that are negative for translocations involving FOXO1, there are two other variant PAX3 translocations that could be present - t(X;2)(q13;q36.1) PAX3-FOXO44 and t(2;2)(q36.1;p23) PAX3-NCOA15.


1. Kodet R et al., Am J Surg Pathol 1993;17(5):443-53

2. Ahn et al., Oncol Rep. 2013 August; 30(2): 968–978

3. Sorensen et al., J Clin Oncol 2002;20:2672-9

4. Barr et al., Cancer Res 2002;62:4704-10

5. Wachtel et al., Cancer Res 2004:64(16):5539-45

Microscope Images

PAX7 Breakapart magnified
Area of Interest*


This product is intended to be used on formalin-fixed paraffin-embedded (FFPE) tissues.

*Disease information supported by the literature and is not a reflection of the intended purpose of this product.