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ROS1 Breakapart

Applications
pathology
Catalogue Numbers
LPS 022 (10 tests)
LPS 022-S (5 tests)

The receptor tyrosine kinase c-ros oncogene 1 (ROS1) is an orphan receptor tyrosine kinase of the insulin receptor family and is located at 6q221. ROS1 consists of a large extracellular domain that is composed of six fibronectin repeats, transmembrane domain, and an intracellular kinase domain. While the function of ROS1 is undefined, it has been shown to play an important role in the differentiation of epididymal epithelium2.

ROS1 rearrangements have been reported to define a molecular subset of Non Small-Cell Lung Cancer (NSCLC)3. Rearrangements of ROS1 with fusion partners SLC34A2 (solute carrier family 34 (sodium phosphate), member 2)4 and CD74 (Cluster of Differentiation 74), have been shown to occur in less than 2% of patients with NSCLC3. Patients harbouring ROS1 rearrangement have been shown to respond to treatment with ALK/MET tyrosine kinase inhibitors, such as Xalkori® (crizotinib)5,6.

ROS1 rearrangements with the fusion partner GOPC (golgi-associated PDZ and coiled-coil motif containing) have also been implicated in Glioblastoma and Cholangiocarcinoma5,7. ROS1 Fusions activate the pSTAT3, PI3K/AKT/mTOR and the SHP-2 phosphatase pathways8,9.

References

1. Matsushime H et al., Mol Cell Biol 1986;6:3000-4

2. Yeung CH et al., Biol Reprod 1999;61:1062-9

3. Bergethon K et al., J Clin Oncol 2012;30(8):863-70

4. Davies KD et al., Cancer Res 2012;72(8):1538-7445

5. Matsuura et al., Oncol Rep. 2013 Oct;30(4):1675-80

6. Ou SH et al., Expert Rev Anticancer Ther 2012;12(4):447-56

7. Yasuda H et al., J Thorac Oncol 2012;7(7):1086-90

8. Birchmeier C et al., Proc Natl Acad Sci 1987;84:9270-9274

9. Gu TL et al., PLoS One 2011;6: e15640

10. Charest A et al., Genes Chromosomes Cancer 2003;37:58-71

Microscope Images

ROS1 Breakapart magnified
Area of Interest*
Glioma, Cholangiocarcinoma (Bile duct), Ovarian Cancer, Lung Cancer

Disclaimer

This product is intended to be used on formalin-fixed paraffin-embedded (FFPE) tissues.

*Disease information supported by the literature and is not a reflection of the intended purpose of this product.