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TMPRSS2/ERG Deletion/Breakapart

Applications
pathology
Catalogue Numbers
LPS 021 (10 tests)
LPS 021-S (5 tests)

Recent studies suggest that over 50% of prostate tumours may carry a chromosomal rearrangement of chromosome 21q221. The genes involved are the androgen-inducible TMPRSS2 (Transmembrane protease, serine 2 (21q22.3)) and an ETS (E-twenty six) family transcription factor, ERG (v-ets erythroblastosis virus E26 oncogene like (21q22.2))1.

An apparent intrachromosomal deletion of 3Mb on chromosome 21 fuses TMPRSS2 to ERG. The rearrangement places ERG under the androgen-regulated transcriptional control of TMPRSS22. This fusion is associated with disease progression and the rearrangement in prostate cancer may account for molecular and clinical heterogeneity3. This represents an important subclassification of prostate cancer from a biological and a clinical standpoint3.

References

1. Saramaki et al., Clin Cancer Res 2008;14(11):3395-3400

2. Lapointe et al., Modern Pathology 2007;20(4):467-473

3. Perner et al., Cancer Res 2006;66(17):8337-8341

Microscope Images

TMPRSS2 ERG Deletion Breakapart magnified
Area of Interest*
Prostate Cancer

Disclaimer

This product is intended to be used on formalin-fixed paraffin-embedded (FFPE) tissues.

*Disease information supported by the literature and is not a reflection of the intended purpose of this product.