FUS Breakapart Probe

Pathology Probes
LPS 050-S (5 tests)
LPS 050 (10 tests)

The FUS (FUS RNA binding protein) gene at 16p11.2 is a member of the FET family of protein-encoding genes, closely-related to the EWSR1 (EWS RNA binding protein 1) gene1.

Recurrent rearrangements involving the FUS gene with a number of different partner genes have been reported in various types of neoplastic disease, notably soft tissue sarcomas and acute myeloid leukaemia. In some tumour types FUS and EWSR1 may replace each other as fusion partners2.

In soft tissue sarcoma, approximately 90% of cases of myxoid liposarcoma are characterised by the presence of a FUS-DDIT3 rearrangement arising from a t(12;16)(q13;p11) translocation3,4; the FUS-CREB3L1 and the FUS-CREB3L2 fusions, resulting from t(11;16) (p11;p11) and t(7;16)( q32-34;p11) translocations respectively are characteristic of low-grade fibromyxoid sarcoma5, whereas the t(12;16)(q13;p11) translocation resulting in a FUS-ATF1 fusion gene is seen in angiomatoid fibrous histiocytoma6.

This breakapart probe has been designed to allow detection of FUS rearrangements regardless of the partner gene involved.

Show references
  1. Göransson, M. et al., Oncogene 2009. 28:270–278
  2. Andersson, M.K. et al., BMC cell biology 2008. 9:37
  3. Willeke, M. et al., Clin Cancer Res. 1998. 4:1779–1784
  4. Panagopoulos, I. et al., Cancer Research 1994. 54:6500–6503
  5. Mertens, F. et al., Laboratory investigation 2005. 85:408-15
  6. Tanas, M.R. et al., Modern pathology 2010. 23:93–7