BCL6 Breakapart LPH035

Rearrangements of the BCL6 gene have been observed in 20-40% of diffuse large B cell lymphoma (DLCL) and in 5-15% of follicular lymphoma (FL) resulting in the deregulation of BCL6. BCL6 functions as a transcriptional repressor and plays an important regulatory role in lymphoid cell development and function. Recently an alternative breakpoint cluster region (ABR) was identified in Non-Hodgkins Lymphomas (NHL) which may be preferentially associated with Follicular Lymphoma.