BCR/ABL Translocation Dual Fusion LPH007

The presence of the Philadelphia chromosome, produced as a result of the Philadelphia translocation t(9;22)(q34;q11), has important diagnostic and prognostic implications in a number of Haematological disorders. The abnormality is characteristic of CML (found in around 90% of cases) but represents a significant abnormality in 30% of adult and 2 to 10% of childhood ALL cases. This rearrangement is also seen in rare cases of AML. The stereotypic translocation fuses the ABL proto-oncogene to the BCR gene, giving rise to the BCR/ABL fusion gene, which is an active Tyrosine Kinase.