IGH/CCND3 Translocation, Dual Fusion LPH040

Approximately 40-60% of multiple myeloma cases are associated with translocations involving the IgH locus. Cases lacking an IgH translocation are associated with hyperdiploid phenotype. The CCND3/IGH translocation t(6;14)(p12-p21;q32) has been reported in 3-4% of multiple myeloma tumours. However it is also characteristic of a variety of other B-cell malignancies including plasma cell leukaemia, diffuse large B-cell non-Hodgkin lymphoma (DLBCL) and splenic marginal zone lymphomas (SMZLs). Cyclin D3 has been identified as a putative oncogene that is dysregulated as the consequence of the translocation.