CKS1B/CDKN2C Amplification Deletion LPH039

Structural abnormalities of chromosome 1 are frequently detected in multiple myeloma, and have been correlated with more advanced disease. Amplification of 1q21 (CKS1B) is one of the most recurrent chromosomal aberrations in multiple myeloma. Over-expression of the CKS1B gene up-regulates cell cycle progression resulting in a more proliferative disease. This is related to the advanced phenotype of multiple myeloma and therefore may be associated with poor prognosis and disease progression and is also observed in disease relapse. CDKN2C (p18) is a tumour suppressor gene responsible for inducing apoptotic cell death and DNA fragmentation, deletion of the gene is associated with a more proliferative disease. Although p18 deletions have been reported to be rare in human malignancy, cytogenetic analysis has shown abnormalities in 16% of human multiple myeloma.