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E2A Breakapart LPH019
Translocations involving the E2A gene have been characterised in childhood B-ALL. At present, there are two partner genes, PBX1 and HLF (on chromosomes 1 and 17 respectively) which become fused to E2A as a result of the t(1;19) and t(17;19) translocations forming the E2A/PBX1 and E2A/HLF fusion proteins respectively. The former is more common, being present in about 5% of paediatric ALLs whilst the other is present in some 1%. Both are associated with poor outcome. Detection of the t(1;19) is best carried out using molecular methods such as FISH as the fusion has been shown to be missed in 20 to 25% of patients by standard cytogenetics.
E2A Breakapart Probe
Cat. No. LPH 019-S (5 tests)
Cat. No. LPH 019 (10 tests)
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