EVI1 Breakapart LPH036

Chromosome rearrangements involving band 3q26.2 are associated with myeloid malignancies, aberrant expression of the human ecotropic virus integration site 1 (EVI1) gene, an unfavourable prognosis and an aggressive clinical course. The EVI1 gene is inappropriately expressed in the leukaemic cells of between 2-5% of AML and MDS patients and follows a chromosomal rearrangement involving 3q26 in the two most common translocations, t(3;3)(q21;q26) and inv(3)(q21q26). The breakpoints differ between translocations and inversions but the three colour strategy of the Cytocell probe has been designed to pick up both with the same product.