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EVI1 Breakapart LPH036
Chromosome rearrangements involving band 3q26.2 are associated with myeloid malignancies, aberrant expression of the human ecotropic virus integration site 1 (EVI1) gene, an unfavourable prognosis and an aggressive clinical course. The EVI1 gene is inappropriately expressed in the leukaemic cells of between 2-5% of AML and MDS patients and follows a chromosomal rearrangement involving 3q26 in the two most common translocations, t(3;3)(q21;q26) and inv(3)(q21q26). The breakpoints differ between translocations and inversions but the three colour strategy of the Cytocell probe has been designed to pick up both with the same product.
EVI1 Breakapart Probe
Cat. No. LPH 036-S (5 tests)
Cat. No. LPH 036 (10 tests)
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