IGH Breakapart LPH014

In ALL, IGH is most notably involved in rearrangements involving the cMYC oncogene as a result of the t(8;14) translocation. However, less common rearrangements of the IGH gene are most often seen in T-ALL and also in B-ALL. There are a number of stereotypical translocations involved in each of the two diseases and more are being described regularly. Involvement of chromosomes 1, 2, 5, 6, 7, 8, 9, 11, 12, 13, 14, 17, 18, 19 and 22 have been described and the two most common translocations are IGH/BCL2 involving the t(14;18) translocation and IGH/CCND1 involving the t(11;14) translocation. With all these rearrangements having breakpoints within the IGH gene, we have designed a split probe set for IGH, which can detect any rearrangement. This involves the splitting of the IGH gene in the region between the Constant and Variable segments thereby identifying the IGH translocation partner chromosome in the less common rearrangements of this gene.