IGH/FGFR3 Translocation, Dual Fusion LPH030

The t(4;14) (p16.3;q32.3) translocation is found in approximately 10% of myeloma patients and results in the deregulation of at least two genes. These are MMSET (Multiple Myeloma SET domain containing protein also known as WHSC1) and FGFR3 (fibroblast growth factor receptor 3) with the formation of a fusion product between MMSET and the immunoglobulin heavy chain (IGH) locus and overexpression of FGFR3 and it has been suggested that FGFR3 expression is switched on by close proximity to the strong enhancer elements in the immunoglobulin heavy chain.