MLL Breakapart LPH013

Rearrangement of the MLL gene can be detected in the leukaemia cells of approximately 85% of infants with B-ALL. Translocations involving the MLL (11q23) gene are generally associated with an increased risk of treatment failure. The most frequently observed of these translocations is the t(4;11) translocation involving the MLL gene and the AF4 gene on chromosome 4. A poor outcome for infants with ALL is strongly associated with the presence of this rearrangement in particular.