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Aquarius® Haematology probes

PDGFB Breakapart Probe LPH031

PDGFRB Breakapart Probe

Some cases of CML have constitutive activation of the gene for PDGFRβ which encodes a receptor for tyrosine kinase. The activation is usually caused by a t(5;12)(q32;p13) translocation which results in the ETV6-PDGFRβ fusion gene. The drug imatinib mesylate (Gleevec) specifically inhibits the kinase activity of PDGFRβ and has shown efficiency in the treatment of chronic myeloid leukaemia and gastrointestinal stromal tumours.

Cytocell Aquarius

PDGFRB Breakapart Probe

Cat. No. LPH 031-S (5 tests)

Cat. No. LPH 031 (10 tests)

PDGFRB Breakapart Probe

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produced in the UK
Cytocell Ltd 3-4 Technopark Newmarket Road Cambridge CB5 8PB United KingdomTel: +44(0) 1223 294048Fax: +44(0) 1223 294986probes@cytocell.com