IGH/c-MYC Translocation, Dual Fusion LPH041

The c-MYC/IGH translocation t(8;14) and the variant forms t(2;8)(p13;q24) and t(8;22)(q24;q11) are found in Burkitt's lymphoma and mature B-cell or Burkitt's type ALL. The t(8;14) is found in approximately 75% of patients with Burkitt's lymphoma. The translocations bring c-MYC into close proximity of the IgH enhancer and result in the up-regulation of c-MYC. Over expression of the transcription factor stimulates gene amplification resulting in uncontrolled cell proliferation, which usually occurs in the late event of tumour progression.