cMYC Breakapart LPH010

Translocations involving the cMYC oncogene are similar in B-ALL as those in Burkitt's Lymphoma. In each case, this results in deregulation of cMYC, increased transcription and neoplastic growth. Patients with cMYC rearrangements were originally thought to have poor prognoses but they do respond well to intensive chemotherapy affording them an increased survival rate. This shows that cytogenetic confirmation of the rearrangement is necessary to manage the patient effectively.