CHIC2 Deletion Probe

The CHIC2 or Cysteine-Rich Hydrophobic Domain 2 is primarily rearranged in patients with AML, fusing with the ETV6 gene on chromosome 12p13 in the translocation t(4;12). The gene is also located in a region commonly deleted during the fusion of FIP1L1 and PDGFRA, which is very common in Hyper-Eosinophillic syndrome/Eosinophillic Leukaemia and is extremely sensitive to imatinib.

The CHIC2 probe, labelled in red, spans the CHIC2 gene and extends 174 kb proximal to the D4S1594 marker. The probe mix also contains subtelomere probe for q arm chromosome 4 (dJ963k6, marker (STS)-4qtel11).