MYB Deletion Probe

Deletions of 6q are the fourth most common chromosome aberrations in B-CLL. In around 10% of cytogenetically abnormal patients there is a deletion of 6q1, the breakpoint for which has been variously reported to be in either 6q13, q15 or q21. The MYB gene (Avian Myeloblastosis Viral Oncogene Homolog) is a homologue of the avian v-myb oncogene and has been shown to be expressed in all immature lymphoid and myeloid T cells but not in mature T or B-cells. It is provided as a marker for 6q as it is situated distal to the most proximal breakpoint of 6q (6q21), in 6q23.3.

The MYB probe is 185 kb, labelled in red and covers the entire MYB gene and 138 kb beyond in the 5’ direction. The probe mix also contains a control probe for the 6 centromere (D6Z1).