Wolf-Hirschhorn Critical Region (WHSCR) Probe

WHSCR: Red Fluorophore
4q Subtelomere Specific Probe (clone dj963K6): Green Fluorophore

Wolf-Hirschhorn syndrome, caused by a partial deletion of a minimum of 165 Kb of chromosome 4 (4p16.3, between D4S166 and D4S3327), is characterised by severe growth deficiency, severe to profound mental retardation with the onset of convulsions in early infancy, microcephaly, sacral dimples and characteristic facies ('Greek helmet appearance').

The Wolf-Hirschhorn Critical Region Probe targets the entire 165 Kb critical region. It is directly labelled with a red fluorophore (Texas Red spectrum) and is supplied with a 4qter subtelomere specific control probe, which is also directly labelled with a green fluorophore (FITC spectrum).