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SRY LPU026 - Detail
SRY (sex-determining region Y) located in band Yp11.2 is the genetic master switch of gonadal differentiation. It encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA binding proteins1. In mammals it triggers the development of undifferentiated gonads into testes 2. Human zygotes with mutations in SRY develop into XY females, while XX zygotes with presence of SRY result in male phenotype with occasional ambiguous genitalia 3, 4. Translocations of the X and Y are rarely reported but often lead to sex reversal 5.
Reference:/Bibliographie/Literatur/Bibliografia
- Sinclair AH et al 1990 Nature 346:240-244
- Koopman P et al 1991 Nature 351:117-121
- Iida T et al 1994 Hum Mol Genet 3:1437-1438
- Kusz K et al 1999 J Med Gene 36: 452-456
- Ellaithi M et al 2006 BMC Ped 6:11
SRY Probe
Cat. No. LPU 026-S (5 tests)
Cat. No. LPU 026 (10 tests)
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