MALT1 Breakapart LPS017

Extranodal marginal zone B-cell lymphoma (MZBCL) of the MALT (Mucosa-Associated Lymphoid Tissue) type is characterized by two main translocations involving MALT; t(11;18)(q21;q21) and t(14;18)(q32;q21). The t(11;18) API2 (BIRC3) /MALT1 translocation is present in 30% of cases of MALT lymphoma, the fusion protein induces NF-ΚB resulting in transcription activation. Eighteen percent of MALT lymphomas harbour the t(14;18) MALT1/IGH translocation.