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MALT1 Breakapart Probe LPS017 - Detail
Extranodal marginal zone B-cell lymphoma (MZBCL) of the MALT (Mucosa-Associated Lymphoid Tissue) type is characterized by two main translocations involving MALT; t(11;18)(q21;q21) and t(14;18)(q32;q21). Other MALT1 associated translocations are rare. However there are no MALT translocations in nodal or splenic lymphomas1. The t(11;18) API2/BIRC3 (Apoptosis Inhibitor2/ Baculovirus IAP repeat containing protein3)/MALT1 translocation is present in 30% of cases of MALT lymphoma2 and the API2-MALT1 fusion protein induces NF-ΚB (nuclear factor kappa-light-chainenhancer of activated B cells) resulting in transcription activation3. Eighteen percent of MALT lymphomas harbour the t(14;18) MALT1/IGH translocation4. The genetic abnormalities in MALT lymphomas reflect their site of origin. The t(14;18) translocation was most frequently found in MALT1 lymphomas of the parotid gland, liver, skin, ocular adnexa; sites rare for the t(11;18). However, the pulmonary and gastrointestinal MALT lymphomas show high frequencies of t(11;18) and absence of t(14;18) 1,4.
Reference:/Bibliographie/Literatur/Bibliografia
- Murga Penas et. al. 2003
- Auer IA et. al. 1997
- Lucas PC et. al. 2001
- Streubel B et. al. 2003
MALT1 Breakapart Probe
Cat. No. LPS 017
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