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MDM2 Amplification LPS016
When the Murine Double Minute (MDM2) gene is over-expressed it enhances the tumourigenic potential of cells. The oncogene product forms a tight complex with the p53 tumour suppressor protein and can inhibit p53 mediated transactivation, leading to escape from p53 regulated growth control. MDM2 has been shown to be amplified in around 7% of human tumours. The use of FISH in well differentiated liposarcoma has been a valuable diagnostic tool.
MDM2 Amplification Probe
Cat. No. LPS 016
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