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MDM2 Amplification Probe LPS016 - Detail
The MDM2 gene, located at 12q14.3-q15, when overexpressed, enhances the tumourigenic potential of cells. The oncogene product forms a tight complex with the p53 tumour suppressor protein and can inhibit p53 mediated transactivation leading to escape from p53 regulated growth control1. The Murine Double Minute (MDM2) gene has been shown to be amplified in around 7% of human tumours. Many tumours overexpress MDM2, the most common being soft tissue tumours 20%, osteosarcomas 16% and oesophageal carcinomas 13%2. The use of FISH in well differentiated liposarcoma has been a valuable diagnostic tool2,4 whilst small-molecule MDM2 inhibitors which could act as an innovative therapeutic tool have also been identified5.
Reference:/Bibliographie/Literatur/Bibliografia
- Momanad J et al. 1992 Cell 69(7): 1237-45
- Momand J 1998 Nuc Acid Res 20(15):3453-3459
- Weaver J et al 2008 Mod Path 21(8):943-9
- Sirvent N et al 2007 Am J Surg Pathol 31(10): 1476-98
- Vassilev LT 2007 13(1):23-31
MDM2 Amplification Probe
Cat. No. LPS 016
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