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PAX3 Breakapart LPS012
Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in children. One of the primary histological subtypes is the alveolar RMS (ARMS). The majority (80%) of ARMS are associated with the t(2;13)(q35;q14) translocation leading to the fusion of transcription factor FKHR to the transcription factor PAX3. Patients with the t(2;13) have a more adverse outcome then patients with t(1;13). In cases of ARMS patients who are negative for FKHR translocation, two variant PAX3 translocation associated fusion transcripts (PAX3-AFX and PAX3-NCOA1) could be present.
PAX3 Breakapart Probe
Cat. No. LPS 0012
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