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Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in children. One of the primary histological subtypes is the alveolar RMS (ARMS)1. The majority (80%) of ARMS are associated with the t(2;13)(q35;q14) translocation and less commonly with t(1;13)(p36;q14) leading to the fusion of transcription factor FKHR (Forkhead in Rhabdomyosarcoma) or FOXO1A (Forkhead Box protein 1) to the transcription factors PAX3 (Paired Box protein 3) and PAX7 respectively. The distinction between t(1;13) and t(2;13) ARMS is important because patients with the t(2;13) have a more adverse outcome then patients with t(1;13) 2. In cases of ARMS patients who are negative for FKHR translocation, two variant PAX3 translocation associated fusion transcripts (PAX3-AFX and PAX3-NCOA1) could be present3,4. The PAX3 and PAX7 probes will distinguish patients with a different outcome for ARMS and will avoid false positive FISH results in ARMS cases when FKHR is not involved in translocations.
Cat. No. LPS 0012
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