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PAX7 Breakapart LPS013
Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in children. One of the primary histological subtypes is the alveolar RMS (ARMS). The majority (80%) of ARMS are associated with the t(2;13)(q35;q14) translocation and less commonly with t(1;13)(p36;q14). The latter translocation resulting in the fusion of transcription factor FOXO1A to the transcription factor PAX7 respectively. The distinction between t(1;13) and t(2;13) ARMS is important because patients with the t(2;13) have a more adverse outcome then patients with t(1;13).
PAX7 Breakapart Probe
Cat. No. LPS 013
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