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The 1p36 region is frequently deleted in a broad range of human cancers. The CHD5 gene acts as a tumour suppressor at 1p36 and is frequently deleted in human gliomas, leukaemia/lymphoma and neuroblastoma. This is the most common childhood extra-cranial solid tumour accounting for around 8%-10% of childhood cancers and 15% of childhood cancer deaths. The CHD5 gene has been characterised as the lead tumour suppressor candidate from the 1p36 SRD (smallest region of consistent deletion) region in neuroblastoma.
Cat. No. LPS 010
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