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The 1p36 region is frequently deleted in a broad range of human cancers1. The Chromodomain Helicase DNA binding domain 5 (CHD5) gene acts as a tumour suppressor at 1p36 and is frequently deleted in human gliomas2, leukaemia/lymphoma3 and neuroblastoma4. Deletion of the short arm of chromosome 1 is one of the most characteristic genetic changes in neuroblastomas, a tumour of the sympathetic nervous system. This is the most common childhood extracranial solid tumour accounting for around 8%-10% of childhood cancers and 15% of childhood cancer deaths5. The CHD5 gene has been characterised as the lead tumour suppressor candidate from the 1p36 SRD (smallest region of consistent deletion) region in neuroblastoma6.
Cat. No. LPS 010
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