SRD (CHD5) Deletion Probe LPS010 - Detail

The 1p36 region is frequently deleted in a broad range of human cancers¹. The Chromodomain Helicase DNA binding domain 5 (CHD5) gene acts as a tumour suppressor at 1p36 and is frequently deleted in human gliomas², leukaemia/lymphoma³ and neuroblastoma⁴. Deletion of the short arm of chromosome 1 is one of the most characteristic genetic changes in neuroblastomas, a tumour of the sympathetic nervous system. This is the most common childhood extracranial solid tumour accounting for around 8%-10% of childhood cancers and 15% of childhood cancer deaths⁵. The CHD5 gene has been characterised as the lead tumour suppressor candidate from the 1p36 SRD (smallest region of consistent deletion) region in neuroblastoma⁶.

Reference:/Bibliographie/Literatur/Bibliografia

1. Bagchi and Mills 2008, Canc Res 68(8):2551-56
2. Bagchi et al. 2007, Cell 128(3): 459-75
3. Maser et al. 2007, Nature 447:966-74
4. Okawa et al. 2008, Oncogene 27:803-10
5. Broudeur and Maris 2006 Neuroblastoma in Principles and Practice of Pediatric Oncology. 5th ed. Philadelphia, PA:Lippincott: 933-970
6. Fujita et al 2008 J Natl Cancer Inst 100: 940-949