SYT Breakapart LPS014

Synovial sarcomas account for up to 10 percent of soft-tissue sarcomas, typically arising in the para-articular regions in adolescent and young adults. A characteristic SYT-SSX fusion gene resulting from the chromosomal translocation t(X;18)(p11;q11) is detectable in 90% of synovial sarcomas suggesting this is the primary causal event in the sarcoma. The translocation fuses SYT to either of two highly homologous genes at Xp11 or SSX1. SYT-SSX1 and SYT-SSX2 are thought to disrupt transcription and the expression of specific target genes.