SYT Breakapart Probe LPS014 - Detail

Synovial sarcomas account for up to 10 percent of soft-tissue sarcomas, typically arising in the para-articular regions in adolescent and young adults¹. A characteristic SYT-SSX fusion gene resulting from the chromosomal translocation t(X;18)(p11;q11) is detectable in 90% of synovial sarcomas suggesting this is the primary causal event in the sarcoma². The translocation fuses the SYT (Synaptotagmin) gene from chromosome 18 to either of two highly homologous genes at Xp11, SSX1 (Synovial Sarcoma X Breakpoint 1) or SSX2 or in less than 1% of cases SSX4³. SYT-SSX1 and SYT-SSX2 are thought to disrupt transcription and the expression of specific target genes^4,5.

Reference:/Bibliographie/Literatur/Bibliografia

1. Fletcher et al 2002 World Health organisation Classification of Tumours IARC Press: Lyon
2. Sreekantaiah et al 1994 Am J Pathol; 144:1121-34
3. Ladanyi et al 2002 Canc Res 62:135-140
4. Ladanyi 1995 Diagn Mol Pathol 4:162-73.
5. Sorensen and Triche 1996 Semin Cancer Biol 1996 7:3-14