TOP2A Amplification/Deletion LPS002

The Topoisomerase 2A encoding cell-cycle regulated protein gene (TOP2A) is located close to the HER2 oncogene and it has a function in DNA replication and transcription of mRNA. Amplification of TOP2A is frequent in breast cancer and is often accompanied by HER-2 amplification. TOP2A gene alterations are associated with an increased benefit from therapy using the anti-cancer drug anthracycline while patients with tumours normal for TOP2A and HER2 do not appear to have additional benefit from usage of this drug.