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ZNF217 Amplification LPS005 - Detail
The Zinc Finger protein 217 gene (ZNF217), which functions as a transcription repressor for a variety of genes1, is a strong oncogene candidate mapped within 260 kb of the minimum common amplicon at 20q13.2. It drives the 20q13.2 amplification in breast cancer2, ovarian cancer and other tumours3,4,5 and is associated with aggressive tumour behaviour6. It has been shown that the silencing of ZNF217 inhibits ovarian cancer cell growth and the invasive ability in cancer cell lines7.
Reference:/Bibliographie/Literatur/Bibliografia
- Quinlan KG et al. 2006 Mol Cel Biol 26: 8159-8172
- Collins C et al. 1998 Proc Natl Acad Sci 95:8703-8708
- Yang SH et al. 2005 Clin Cancer Res 11:612-620
- Iwabuchi H et al 1995 Cancer Res 55: 6172-6180
- Bar-Shira A. et al. 2002 2002 Cancer Res 62: 6803-6807
- Tanner MM et al. 1995 Ciln CancRes 1:1455-1461
- Sun G et al 2008 It J of Oncol 32:1065-1071
ZNF217 Amplification Probe
Cat. No. LPS 005
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