ZNF217 Probe LPS005 - Detail

The Zinc Finger protein 217 gene (ZNF217), which functions as a transcription repressor for a variety of genes¹, is a strong oncogene candidate mapped within 260 kb of the minimum common amplicon at 20q13.2. It drives the 20q13.2 amplification in breast cancer², ovarian cancer and other tumours^3,4,5 and is associated with aggressive tumour behaviour⁶. It has been shown that the silencing of ZNF217 inhibits ovarian cancer cell growth and the invasive ability in cancer cell lines⁷.

Reference:/Bibliographie/Literatur/Bibliografia

1. Quinlan KG et al. 2006 Mol Cel Biol 26: 8159-8172
2. Collins C et al. 1998 Proc Natl Acad Sci 95:8703-8708
3. Yang SH et al. 2005 Clin Cancer Res 11:612-620
4. Iwabuchi H et al 1995 Cancer Res 55: 6172-6180
5. Bar-Shira A. et al. 2002 2002 Cancer Res 62: 6803-6807
6. Tanner MM et al. 1995 Ciln CancRes 1:1455-1461
7. Sun G et al 2008 It J of Oncol 32:1065-1071