C-MET Amplification LPS004 - Detail

The c-MET (Mesenchymal-Epithelial Transition factor) or Hepatocyte Growth Factor Receptor (HGFR) gene encodes for a transmembrane tyrosine kinase¹ which is a proto-oncogene. The c-MET gene regulates both cell motility and cell growth² so normal c-MET expression allows stem cells and progenitor cells to grow invasively. This invasive growth is required to generate new tissues in an embryo, or in an adult in regenerating tissue such as in the liver or during wound repair³. c-MET has been shown to be overexpressed in many tumours: ovarian⁴, breast⁵, lung⁶, thyroid⁷, stomach⁸, pancreatic^9,10 and colon cancer^11,12 and this overexpression correlates with a poor prognosis. In breast cancers, c-MET was shown to be only co-expressed with HER2 in 50% of patients, indicating that it has a significant impact on tumour aggressiveness independent of HER2¹³.

Reference:/Bibliographie/Literatur/Bibliografia

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13. Lengyel E. et la 2005 N. Int J. Canc