EGFR Amplification LPS003

EGFR (also known as HER1) Epidermal Growth Factor Receptor is a type I tyrosine kinase receptor for members of the epidermal growth factor family. Binding of the EGFR to epidermal growth factor protein leads to cell proliferation. Abnormally elevated EGFR kinase activity can lead to proliferative diseases such as non-small-cell lung carcinoma (NSCLC), which accounts for 80-85% of all lung cancers and less frequently in breast cancer amongst others. FISH has proven to be useful for determining the status and therefore selection of patient treatment with Tyrosine Kinase Inhibitors (TKIs).