Subtelomere specific probes

The importance of subtelomeric chromosome rearrangements has been clearly shown by their observed association with unexplained mental retardation and congenital abnormalities.

Individual subtelomere specific probes have been used to focus on particular subtelomeric regions and have resulted in the establishment of new syndromes as the chromosome 1p36 deletion syndrome and the 22q13.3 deletion syndrome. The probes are also finding applications in the investigation of autistic disorders, recurrent miscarriages and haematological malignancies.

Cytocell offers a complete set of liquid subtelomere specific probes identifying 41 of the 46 human subtelomeres with the exclusion of the p-arm telomeres of the acrocentric chromosomes. The probes are available independently and directly labelled in either a red or a green fluorophore (Texas Red or FITC spectra respectively).

The probes have been chosen from the most distal unique sequence to provide the best possible chromosome specificity whilst also being the most subtelomeric probes available that are capable of being used routinely to examine subtelomere enumeration and integrity.

The probes are produced in an economical 5 test format and are concentrated to allow the mixing, if required, of up to 3 Aquarius subtelomere specific probes in the same hybridisation.

The probe mixtures are designed for fluorescence in situ hybridisation of interphase cells and metaphase chromosomes from cultured peripheral blood cells.

Related Products

Chromoprobe Multiprobe-T System

The Chromoprobe Multiprobe-T System combines Cytocell’s Chromoprobe Multiprobe technology with a complete set of subtelomere probes to allow the simultaneous analysis of all subtelomeric regions of every chromosome on one slide in one hybridisation. It consist of a Multiprobe glass device with 24 squares, each one carrying the subtelomere specific probes for both the p-arm and the q-arm of one of the 23 chromosomes reversibly labelled in a red fluorophore (Texas Red spectrum).