Hyperdiploidy Probes

Approximately 30% of cases have cells that exhibit a chromosome number between 51 and 67. Within this region are prognostically significant subgroups, with individuals possessing 51 to 55 chromosomes having a poorer prognosis than those with 56 to 67. The chromosomes that are more readily hyperdiploid are chromosomes 4, 6, 10, 14, 17, 18, 21 and X, with gains of chromosomes 4, 10 and 6 leading to a relatively better prognosis.