Cytocell was established in 1991 at Birmingham Heartlands Hospital before moving to Banbury, Oxfordshire in 1994. Since 2003, Cytocell has been located in Cambridge where we design and manufacture an ever-increasing range of fluorescence in situ hybridisation (FISH) probes.
Cytocell is a significant European manufacturer of FISH probes and has a well-established worldwide distribution network for its products, covering more than 60 countries.
In February 2014, Cytocell was acquired by Oxford Gene Technology (OGT), a leading provider of innovative genetics research solutions. The Group's CytoSure™ microarray products, Cytocell FISH probes and SureSeq™ next generation sequencing (NGS) products provide the complete solution for high-resolution genetic analysis.
Cytocell Product Ranges
The Aquarius range consists of directly labelled FISH probes for constitutional cytogenetic and oncology (both pathology and haematology) applications.
All Aquarius probes are supplied in hybridisation solution and are either ready to use or need simple dilution with additional hybridisation solution which is conveniently supplied in the kit.
The satellite, subtelomere specific and whole chromosome painting probes are available in a 5 test format whereas the microdeletion syndrome and haematology probes are available in an economical 5 and standard 10 test format. The probes are supplied with DAPI counterstain and full instructions for use and, where applicable, with hybridisation solution.
The Chromoprobe Multiprobe® System is an extension of Cytocell's proprietary Chromoprobe® technology whereby DNA FISH probes are reversibly bound to the surface of a glass device. The probes attached to the glass device dissolve back into solution once in contact with hybridisation buffer, whilst denaturation of the probes and target DNA occurs simultaneously under the device once heated. This approach both simplifies the whole FISH procedure and renders it safer and quicker to use.
This system allows multiple FISH probes to be hybridised on the same slide in a spatially separated manner allowing rapid screening of a patient sample for a number of DNA sequences in a single FISH analysis.
The assay is supplied in a kit format of 2, 5, 10 or 20 slides and includes hybridisation solution, counterstain, template slides, a hybridisation chamber and full instructions for use. The kit also contains a unique liquid crystal display slide surface thermometer for accurate measurement of the temperature of the denaturation surface.
myProbes® Custom FISH Probes
myProbes is a custom design and manufacture service that provides unique fluorescence in situ hybridisation (FISH) probes using the BAC-2-FISH™ process. This process utilises Cytocell’s proprietary BAC clone collection containing >220,000 clones to produce fully quality-assured custom FISH probes for virtually any sequence in the entire human genome.
Based on your specific interests and research, custom FISH probes may range from a simple catalog probe modification to a truly unique product.
ZooFISH covers our non-human FISH probe capabilities. This includes our ZooFISH Range comprised of Cytocell Chromoprobe Multiprobe OctoChrome Murine, Cytocell Chromoprobe Multiprobe Porcine and Cytocell Chromoprobe Multiprobe Chicken. It also includes our comprehensive range of Murine Whole Chromsome Painting Probes for the assessment of chromsome number, breakage or rearrangement.
Various hybridisation solutions and DAPI counterstain are available as separate items.