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BCL6 Breakapart

Catalogue Numbers
LPH 035-S (5 tests)
LPH 035 (10 tests)

Probe Specification

  • BCL6, 3q27.3, Red
  • BCL6, 3q27.3, Green

The BCL6 product consists of a 165kb probe, labelled in red, centromeric to the BCL6 gene and a green probe, covering a 170kb region telomeric to the BCL6 gene.

Probe Information

Rearrangements of the BCL6 gene have been observed in 28.6-35.5% of Diffuse Large B-Cell Lymphoma (DLBCL) and in 6.4-14.3% of Follicular Lymphoma (FL)1.

This translocation results in the dysregulation of BCL6 and may involve the IGH, IGK and IGL genes, although other non-Ig partner genes have also been identified2,3. BCL6 encodes a 95kD nuclear phosphoprotein belonging to the pox virus zinc finger (POZ)/zinc finger (ZF) family of transcription factors4. BCL6 functions as a transcriptional repressor and plays an important regulatory role in lymphoid cell development and function. In the B-cell lineage, the BCL6 protein is expressed only in germinal centre B cells5. Translocations involving band 3q27.3 affect a 4kb major breakpoint region of BCL6 in the first non-coding exon and 5' region of the first intron, and are common in diffuse large B-cell lymphomas. Recently, an alternative breakpoint cluster region located between 245 and 285kb 5' of BCL6 was identified in Non-Hodgkin Lymphoma (NHL) and may be preferentially associated with follicular lymphoma6.

I am grateful for the excellent products I receive from Cytocell at a reasonable price, but more importantly the superb customer support.  The speed in which I receive answers or suggestions makes my life as a director much easier and allows me to focus on patient care.  The quality and consistency of Cytocell’s probes means I can trust the results, and my clients get their results in a timely manner. Dr. Theresa C. Brown, Director, Cytogenetics Laboratory, Hayward Genetics Center, Tulane University School of Medicine


1. Ohno H et al., Leuk Lymphoma 1997;27:53-63

2. Ueda C et al., Leuk Lymphoma 2002;43:1375-81

3. Akasaka H et al., Cancer Res 2000;60:2335-41

4. Chang CC et al., PNAS 1996;93:6947-52

5. Cattoretti G et al., Blood 1995;86:45-53

6. Bosga-Bouwer AG et al., Genes Chrom Cancer 2005;44:301-4

Microscope Images

BCL6 Breakapart magnified
Area of Interest*


This product is intended to be used on Carnoy’s solution (3:1 methanol/acetic acid) fixed haematological samples.

*Disease information supported by the literature and is not a reflection of the intended purpose of this product.