MLL/MLLT1 Translocation, Dual Fusion
- MLL, 11q23.3, Green
- MLLT1, 19p13.3, Red
The MLL probe, labelled in green, covers a 200kb region including the MLL (KMT2A) gene. The MLLT1 probe, labelled in red, consists of two clones (203kb and 226kb) that flank the MLLT1 gene.
Translocations involving chromosome 11q23 frequently occur in both acute myeloid leukaemia (AML) and acute lymphoblastic leukaemia (ALL). In most cases, the MLL gene is involved but translocation partners are extremely variable, with 79 direct translocation partners having been molecularly characterised so far.
The most common MLL rearrangement in both AML and ALL involves fusion of the MLL and AFF1 (AF4) genes via a t(4;11)(q21;q23) translocation. Three of the other more common translocations involve the MLLT3 (AF9) gene on chromosome 9, the MLLT1 (ENL) gene on chromosome 19 or the MLLT4 (AF6) gene on chromosome 6.
• MLL/MLLT3(AF9) - t(9;11)(p22;q23)
• MLL/MLLT1(ENL) - t(11;19)(q23;p13.3)
• MLL/MLLT4(AF6) - t(6;11)(q27;q23)
We now have a range of Research Use Only (RUO) Translocation, Dual Fusion probes to allow specific detection of these MLL rearrangements.
I am grateful for the excellent products I receive from Cytocell at a reasonable price, but more importantly the superb customer support. The speed in which I receive answers or suggestions makes my life as a director much easier and allows me to focus on patient care. The quality and consistency of Cytocell’s probes means I can trust the results, and my clients get their results in a timely manner. Dr. Theresa C. Brown, Director, Cytogenetics Laboratory, Hayward Genetics Center, Tulane University School of Medicine
• Meyer et al., Leukemia 2013;27(11):2165-76
- Area of Interest*
- ALL, AML
For research use only, not for use in diagnostic procedures.
*Disease information supported by the literature and is not a reflection of the intended purpose of this product.