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PDGFRB Breakapart

Applications
haematology
Catalogue Numbers
LPH 031 (10 tests)
LPH 031-S (5 tests)

Some cases of Chronic Myelomonocytic Leukaemia (CMML) have constitutive activation of the gene for PDGFRB (platelet derived growth factor receptor beta) which encodes a receptor tyrosine kinase1.

The activation is usually caused by a t(5;12)(q32;p13) translocation which results in the ETV6 (TEL)-PDGFRB fusion gene. Patients with this fusion have reportedly been shown to be responsive to the drug imatinib mesylate (Gleevec)1, which specifically inhibits the kinase activity of PDGFRB. The breakpoint in PDGFRB is characteristically located in intron 102,3.

I am grateful for the excellent products I receive from Cytocell at a reasonable price, but more importantly the superb customer support.  The speed in which I receive answers or suggestions makes my life as a director much easier and allows me to focus on patient care.  The quality and consistency of Cytocell’s probes means I can trust the results, and my clients get their results in a timely manner. Dr. Theresa C. Brown, Director, Cytogenetics Laboratory, Hayward Genetics Center, Tulane University School of Medicine

References

1. Apperley JF et al., N Engl J Med 2002;347:481-7

2. Tokita K et al., Leukemia 2007;21:190-2

3. Levine et al., Leukemia 2005;19:27-30

Microscope Images

PDGFRB Breakapart magnified
Area of Interest*
MPN

Disclaimer

This product is intended to be used on Carnoy’s solution (3:1 methanol/acetic acid) fixed haematological samples.

*Disease information supported by the literature and is not a reflection of the intended purpose of this product.