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IGH/MALT1 Translocation, Dual Fusion

Applications
haematopathology
Catalogue Numbers
LPS 034 (10 tests)
LPS 034-S (5 tests)

The t(14;18)(q32;q21) involving the Immunoglobulin heavy chain locus (IGH) at 14q32 and the Mucosa Associated Lymphoid Tissue Lymphoma Translocation gene 1 (MALT1) at 18q21 is a recurrent abnormality in MALT lymphoma1.

Extranodal marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue is listed as a distinct clinicopathologic entity. MALT lymphomas comprise 7.6% of all non-Hodgkin lymphoma's (NHLs) and represents 1 of the 6 most common NHLs2. MALT lymphomas are characterised by a proliferation of neoplastic marginal zone-related cells that invade the epithelial structures to generate lymphoepithelial lesions and colonise reactive lymphoid follicles3. t(14;18)/IGH-MALT1- positive MALT lymphomas originate in sites such as the liver, skin, ocular adnexa, or salivary glands1. The molecular characteristics of the t(14;18) resemble those found in the t(14;18)/IGH-BCL2 (follicular lymphoma) and t(11;14)/MALT1-IGH (mantle cell lymphoma), suggesting that these translocations could be generated by common pathomechanisms involving illegitimate V(D)J-mediated recombination of IGH as well as non-homologous end joining (NHEJ) or alternative NHEJ repair pathways1.

The quality of the products we have received from Cytocell have been excellent. The FISH probes they provide to us give intense, strong signals and are a pleasure to count. What has really stood out however has been the level of support and assistance provided by Cytocell’s application specialists. The team worked very closely alongside our own during the adoption of this product and spent many hours with us perfecting the technique, going above and beyond what I would expect during the transition period. Source BioScience absolutely demand high quality products and service to be able to deliver our results with confidence, and that is what we have received from Cytocell. Neil Ryan, Laboratory Operations Manager at Source BioScience

References

1. Murga Penas EM et al., Blood 2010;115(11):2214-9

2. Streubel B et al., Blood 2003;101:2335-2339

3. Bacon et al., J Clin Pathol 2007;60:361–372

Microscope Images

IGH MALT1 Translocation Dual Fusion magnified
Area of Interest*
Lymphoma

Disclaimer

This product is intended to be used on Carnoy’s solution (3:1 methanol/acetic acid) fixed haematological samples, or formalin-fixed paraffin-embedded (FFPE) tissues.

*Disease information supported by the literature and is not a reflection of the intended purpose of this product.