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EML4 Breakapart

Catalogue Numbers
LPS 020-S (5 tests)
LPS 020 (10 tests)

Probe Specification

  • EML4, 2p21, Red
  • EML4, 2p21, Green

The EML4 Breakapart probe consists of a green 406kb probe and a red 353kb probe, which are positioned on each side of the EML4 gene.

Probe Information

The protein encoded by the echinoderm microtubule associated protein-like 4 (EML4) gene is involved in microtubule formation and stabilisation1.

A novel gene fusion of EML4 and Anaplastic Lymphoma Kinase (ALK) was recently identified in Non-Small Cell Lung Cancer (NSCLC).

The EML4-ALK fusion was shown to result from an inversion within chromosome 2p, inv(2)(p21p23), and was detected in approximately 7% of NSCLC cases2,3.

It was very important for us to have more consistent results with our probes — easy-to-read bright signals and a range of vial sizes, which is much more cost-effective. It also was critical to upgrade our pretreatment kit to expedite the analysis of FFPE samples. We can now complete the process in about 90 minutes. Janet M. Cowan, PhD, Director of the Cytogenetics Laboratory at Tufts Medical Center


1. Xuchao Zhang et al., Mol Cancer Res 2010;9:188

2. Lin et al., Mol Cancer Res 2009;7(9):1466-1476

3. Martelli et al., AJP 2009;174(2):661-670

Microscope Images

EML4 Breakapart magnified
Area of Interest*
Lung Cancer


This product is intended to be used on formalin-fixed paraffin-embedded (FFPE) tissues.

*Disease information supported by the literature and is not a reflection of the intended purpose of this product.