IGH Plus Probe Range Brochure
IGH is involved in a large number of different rearrangements with fusion partners on almost every other chromosome. Many of these rearrangements have been reported in only one or a few cases but some are more common, such as IGH/BCL2, caused by the t(14;18) translocation1, and IGH/CCND1, a result of the t(11;14) translocation2.
All these rearrangements do, however, have breakpoints within the IGH locus. We have designed a split probe set for IGH, which allows the detection of rearrangements, regardless of the partner gene involved, and a range of Translocation, Dual Fusion probes to allow identification of specific rearragements.
1. Huret JL . t(14;18)(q32;q21) (IgH/BCL2); t(2;18)(p11;q21); t(18;22)(q21;q11). Atlas Genet Cytogenet Oncol Haematol
2. Huret JL . t(11;14)(q13;q32). Atlas Genet Cytogenet Oncol Haematol. May 1998