E2A/PBX1 Plus Translocation, Dual Fusion Probe
The TCF3 (transcription factor 3) gene is located at 19p13.3, PBX1 (pre-B-cell leukemia homeobox 1) gene is located at 1q23.3 and HLF (hepatic leukemia factor) at 17q22.
Translocations involving TCF3 are some of the most common rearrangements in childhood B-cell acute lymphoblastic leukaemia (ALL)1,2. PBX1 and HLF become fused to TCF3 as a result of the t(1;19)(q23;p13) and t(17;19)(q22;p13) translocations, forming the TCF3-PBX1 and TCF3-HLF fusion genes, respectively. A rare cryptic inversion, inv(19)(p13;q13), has been reported to fuse TCF3 to TFPT (TCF3[E2A] fusion partner [in childhood leukaemia]), resulting in the TCF3-TFPT fusion gene1.
1. Van der Burg et al., Leukemia 2004;18(5):895-908
2. Swerdlow et al., editors, WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, Lyon, France, IARC:2008
- Area of Interest*
This product is intended to be used on Carnoy’s solution (3:1 methanol/acetic acid) fixed haematological samples.
*Disease information supported by the literature and is not a reflection of the intended purpose of this product.