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RARα (RARA) Breakapart

Applications
haematology
Catalogue Numbers
LPH 065 (10 tests)
LPH 065-S (5 tests)

Acute Promyelocytic Leukaemia (APL) is associated with chromosomal rearrangements involving the retinoic acid receptor α (RARA) gene, on chromosome 17q21.1-q21.2, and various partner genes situated on different chromosomes2.

In the vast majority of APL cases, the RARA gene fuses with the Promyelocytic Leukaemia (PML) gene located on chromosome 15q24, as a result of a t(15;17) translocation, but RARA fusions with Promyelocytic Leukemia Zinc Finger (PLZF (now known as ZBTB16), 11q23.2), Nucleophosmin (NPM1, 5q35.1), Nuclear Mitotic Apparatus protein 1 (NUMA1, 11q13.4), Myeloid/lymphoid or Mixed Lineage Leukaemia (MLL (KMT2A), 11q23.3) and FIP1-like-1 (FIP1L1, 4q12) genes have also been described1,2,3. The RARAα (RARA) Breakapart probe will detect rearrangements of the RARA gene, irrespective of partner genes or chromosomes involved.

References

1. Melnick A, Licht JD, Blood 1999;93(10):3167-215

2. http://atlasgeneticsoncology.org/Genes/RARAID46.html

3. Rohr et al., Med Oncol 2011;29(4):2345-7

Microscope Images

RARA (RARA) Breakapart magnified
Area of Interest*
AML, APL

Disclaimer

This product is intended to be used on Carnoy’s solution (3:1 methanol/acetic acid) fixed haematological samples.

*Disease information supported by the literature and is not a reflection of the intended purpose of this product.